Grand Rounds – Evolutionary Medicine Series
Wednesday, February 1, 2017
|Barbara Natterson-Horowitz, M.D.
Professor of Medicine, UCLA Division of Cardiology
Co-Director, Evolutionary Medicine Program at UCLA
“The Origins of Heart Disease: 4.3 Billion Years of Insights for Clinicians”
Wednesday, February 8, 2017
|Molly Fox, Ph.D.
Departments of Anthropology and Psychiatry & Biobehavioral Sciences at UCLA
“The Grandmother Paradox: Alzheimer’s Disease and the Evolution of Human Longevity”
The crucial role of grandmothers in the human family may be the key to understanding how evolutionary forces shaped the human lifespan. However, the high rates of Alzheimer’s disease among the elderly undermine prevailing theories about family dynamics and natural selection throughout human history.
I will present the results of a case-control study investigating how women’s reproductive histories affect Alzheimer’s risk via long-term alterations in endocrine, immune, and metabolic systems. I will also present the results of an epidemiological study investigating how environmental pathogen diversity is associated with global variation in age-adjusted Alzheimer’s rates via alterations in individuals’ immunological development.
The ultimate aim of my Alzheimer’s research is to use modern information to reconstruct what disease risk might have been in pre-modern human environments, in order to explore elderly women’s cognitive competence and evaluate the evolutionary dynamics that led to natural selection for human longevity.
Wednesday, February 15, 2017
|William Audeh, M.D.
Associate Clinical Professor of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA
Chief Medical Officer, Agendia, Inc.
“Applying Evolutionary Biology to Cancer Medicine”